Designed for steers fed in confinement, Revalor-XS delivers the same proven combination of trenbolone acetate and estradiol used in the Revalor-IS/S program, accompanied by new delayed-release technology. The first dose goes to work immediately after implant, just like Revalor-IS. The second dose, shielded by the patented X7™ polymer coating, goes to work after 70-80 days on feed – delivering the performance of a Revalor-S terminal implant. End Section

Each implant contains ten pellets: four uncoated and six coated with the proprietary X7 polymer. Each pellet contains 20 mg of TBA and 4 mg of estradiol for a total dose of 200 mg of trenbolone acetate and 40 mg of estradiol.

The following study compares the pharmacokinetic profiles of trenbolone and estradiol in beef cattle with two different treatments – Revalor-XS and Revalor-IS/S.

Study details:
A total of 20 animals were used in the study. One group of ten was treated with a Revalor-XS implant on Day 0. A second group of ten was treated with a Revalor-IS implant on Day 0 and a Revalor-S terminal implant on Day 70. For both groups, blood levels of trenbolone acetate and estradiol were measured twice per week for 200 days. The time period was measured in two phases, Day 0 to 70 for Phase 1 and Day 71 to 200 for Phase 2. Applicable measures for this study are area under curve (AUC) – used to measure overall and phase-specific blood levels, Cmax – the maximum observed concentration in the body after dosing, and Tmax – the time to maximum plasma concentration.

Trenbolone Acetate Blood Levels:

TBA Results:
• No statistical difference in AUC or Cmax between treatments
• Phase 2 Tmax later (154 days) for Revalor-XS

Conclusion:
As you can see from the Pharmacokinetic data, Revalor-XS delivered more consistent levels of TBA and estradiol throughout the course of the study. Coupled with the lack of stress from reprocessing, Revalor-XS should significantly improve feed intake and weight gain throughout treatment.

The new Rev-X Universal Implant Tool works with ALL Revalor and Finaplix products, and is the preferred method for implanting Revalor-XS implants. It features a longer needle and plunger to ensure full insertion of the entire 10-pellet implant.

Your existing Revalor implant tool can be used with Revalor-XS implants, but extra care must be taken so that the needle is fully inserted, ensuring proper placement of all ten implant pellets. As always, correct implanting technique and sanitation is crucial to the success of any implant program. If you’re interested in providing implant technique training to your processing crew, contact your Intervet sales representative.

Regardless of the re-implant program being used, cattle that are reprocessed show a marked drop in feed intake. The graph below from a feed intake observation illustrates the decrease associated by reprocessing.*

• On Day 70 prior to re-implanting, feed intake was 20.3 lb./head/day. Six days following re-implanting, feed intake dropped to a low of 15.8 lb./head/day.
• It then took an additional 32 days to return to a feed intake level equal to that at the time of re-implanting.
• The total feed consumption loss for the 38 days was 53.5 lb.

Reimplant Feed Intake Observation:

* Data gathered from a previous research trial not comparing reimplant programs to Revalor-XS.

A performance evaluation of Revalor-XS in finishing steers is summarized in the table below. As the data shows, over the entire feeding period, implanted steers were 114 lb. to 127 lb. heavier on a live basis and 123 lb. to 139 lb. heavier on a carcass basis at slaughter than steers that were not implanted. Overall ADG by implanted steers was 22.3% to 25.0% greater than non-implanted steers. Implanted steers also consumed 10.7% more dry matter than non-implanted steers, which resulted in feed efficiency being improved from 10.1% (live basis) to 12.1% (carcass basis).

Steer DMI was greater for steers receiving Revalor-XS than for steers receiving Revalor-IS/S, but ADG and feed efficiency did not differ significantly between the two.

In summary, steers receiving Revalor-XS or Revalor-IS/S displayed greater ADG (22%), higher dry matter intake (10%) and improved feed efficiency (10%) compared to non-implanted steers. This trial concludes that with the use of Revalor-XS in long-fed steers, re-implanting is not necessary.

Growth performance by steers receiving either no implant,
a reimplant of Revalor-IS/S, or Revalor-XS^a

a Revalor-IS/S = Revalor-IS on Day 0 and Revalor-S on Day 75. Steers receiving Revalor-XS received the implant on Day 0 only, but all cattle were removed from the pen on Day 75.
b Contrast 1 = Nonimplanted vs implanted and 2 = Revalor-IS/S vs Revalor-XS. Statistical significance is identified as ** = P < 0.01 and * = P < 0.05.
c A 4% pencil shrink was applied to full weight.
d Final shrunk weight was calculated as pen hot carcass weight ÷ (overall dressing percent ÷100).
e Calculated according to equations described by Guiroy et al. (2001; Journal of Animal Science 79:1983).
f Data from Revalor-XS Tech Bull #1 .

Dependable labor resources are difficult to find – and expensive. As noted in the graph below, although the number of feedyard employees per 1000 head of cattle has gradually declined over the last 15 years, the cost and expense of maintaining these employees has increased dramatically. Given this investment, it’s important that your labor be utilized in a way that can best benefit the feedyard and its management goals. Revalor-XS frees up labor resources from re-implanting, allowing you to reallocate and maximize labor resource efficiency.

Employee Rate and Cost Over Time:

• Revalor-XS is the first approved product from an animal health company that has successfully implemented Process Analytical Technology (PAT) in the manufacturing process.
• Intervet uses Near Infrared (NIR) Spectroscopy for real-time in-process assessment of polymer coating layer thickness of the Revalor-XS pellets.
• The NIR probe is placed inside the coater allowing for continuous control of the coating thickness during the whole coating process.
• Integration of this analytical technique gives Intervet the ability to monitor all pellets during the process instead of taking only a few samples at the end of the process – ensuring a quality final product.